Liz Truss will lose to Reform UK by just 970 votes, Electoral Calculus' estimate of tonight's exit poll has revealed.
The former Prime Minister, who was seeking re-election in South West Norfolk, was defending a majority of 26,195 votes.
Such a result would be a massive electoral upset and represent a major breakthrough for Reform UK.
The populist party looks poised to pick up 13 seats, with the Tories collapsing to just 131.
Electoral Calculus expects Farage to win in Clacton by around 4,304 votes, with Richard Tice also poised to pick up Boston & Skegness by a margin of 3,242.
Reform UK is also predicted to fall agonisingly short of picking up Louth & Horncastle from Health Secretary Victoria Atkins.
Tory Party insiders feared a resurgent Reform following Farage's return as leader just a few weeks before polls opened.
Responding to the exit poll, a Conservative source told OceanNewsUK: "I hope Reform voters regret what they have done."
However, Truss is not the only Tory big wig at risk of being ousted.
Labour will return with a massive majority after being predicted to return 410 MPs.
Tory Party chairman Richard Holden, Defence Secretary Grant Shapps, Common Sense Minister Esther McVey, Veterans Minister Johnny Mercer, former Business Secretary Jacob Rees-Mogg and Attorney General Victoria Prentis all face being defeated by Labour challengers.
The Liberal Democrats could also topple Chancellor Jeremy Hunt, Justice Secretary Alex Chalk and Science Secretary Michelle Donelan.
Chief Whip Simon Hart could even miss out to Plaid Cymru by 5,941 votes.
However, it is not all good news for Starmer's Labour Party.
Former Labour leader Jeremy Corbyn looks set to retain Islington North, with Workers Party leader George Galloway also performing well in Rochdale.
The Green Party could also pick up Bristol Central from Shadow Commons Leader Thangam Debbonaire.
