Tottenham are close to agreeing a deal for Genoa defender Radu Dragusin for a fee of about 25m euros (£21.5m) plus add-ons.
Defender Djed Spence, who has just returned to Spurs after an unsuccessful loan at Leeds United, could join Genoa on loan for the rest of the season as part of the deal.
Dragusin has started all 22 of Serie A side Genoa's matches this season.
Bayern Munich have also shown interest in the 21-year-old Romanian.
Dragusin came through the ranks at Juventus and spent time on loan with Genoa before making the move permanent last summer.
Tottenham have been in the market for a centre-back to support Cristian Romero and Mickey van de Ven, who have both suffered with injuries this season.
Spurs manager Ange Postecoglou has played full-backs Ben Davies and Emerson Royal in central defence in recent weeks to cover injuries in the back line.
Eric Dier has also been out of favour with Postecoglou, who said they can afford to lose the defender, and Bayern are reported to be in for the England international.
Dier, 29, has been capped 49 times by England but struggled to claim a first-team place for Tottenham this season, and reports in Germany say he is close to a move to the Bundesliga champions.
Meanwhile, Spence's season-long loan deal at Leeds was cut short and he returned to the club after making only seven appearances in the Championship.
