The charge of a former gang leader with the murder of Tupac Shakur 1996 is a "pivotal moment", the late rapper sister's says.
The New York-born hip-hop legend was shot four times aged 25 in a drive-by attack in Las Vegas.
On Friday, Nevada's grand jury indicted Duane "Keffe D" Davis, 60, on one count of murder with a deadly weapon.
Sekyiwa Shakur said that "today is a victory" but "reserved judgement" until legal proceedings were complete.
"It's important to me that the world, the country, the justice system, and our people acknowledge the gravity of the passing of this man, my brother, my mother's son, my father's son," she posted on Instagram.
"There have been multiple hands involved and there remains so much surrounding the life and death of my brother Tupac and our Shakur family overall. We are seeking real justice, on all fronts," she continued.