Five members of a family have died in a house fire in west London.
Children are among the victims, Ruth Cadbury, MP for Brentford and Isleworth, said.
Ten fire engines and around 70 firefighters from London Fire Brigade were called to a terraced house in Channel Close, Hounslow, on Sunday evening.
One person remains unaccounted for and another left the property before crews arrived and was taken to hospital.
His injuries are not believed to be life-threatening, the Met Police said.
Firefighters discovered the bodies of five people on the first floor. The blaze destroyed the ground floor, first floor and part of the roof.
In an X post, the MP said: "I am devastated to learn this morning that five people, including children, died in a fire in a house in Hounslow last night.
"My thoughts are with their family, friends neighbours."
London Fire commissioner Andy Roe has offered his condolences to the families of the five people.
He said: "This is a terribly sad incident and the thoughts of all of us at London Fire Brigade are with the family, friends and all those affected at this difficult time.
"Staff will be in the local community today to offer support and advice where needed.
"The welfare of our staff is very important and all those involved will be offered support from our counselling and trauma service."
The cause of the fire is under investigation and no arrests have been made.
Nearby properties were evacuated as a precaution.
Ch Supt Sean Wilson, responsible for policing in Hounslow, added: "My thoughts are with the loved ones of those who very sadly lost their lives in this tragic incident.
"I don't underestimate the impact that this will have on the wider community and beyond.
"I understand that there will be a demand for answers and my officers are working to establish exactly what has happened."
Emergency services were called at 22:30 GMT and the fire was under control by 01:25.
Fire crews from Heston, Southall, Twickenham, Hayes, Feltham and surrounding fire stations attended the scene.
