Cole Palmer, Ezri Konsa and Rico Lewis have been called up to the England squad for the first time.
The addition of the trio for two Euro 2024 qualifiers follows the withdrawal of James Maddison, Callum Wilson and Lewis Dunk because of injury.
Chelsea forward Palmer and Manchester City defender Lewis have been elevated from the England Under-21 squad to Gareth Southgate's senior side.
England play Malta on 17 November and North Macedonia on 20 November.
Real Madrid midfielder Jude Bellingham is a doubt for the games because of a shoulder injury.
"The majority of Gareth Southgate's squad are due to report to St George's Park on Monday with further assessments to take place," said an England statement.
Palmer, 21, was part of the England U21 side which won the European Championship in the summer and has been in impressive form for Chelsea this season.
He joined the Blues from Manchester City in the summer and scored a penalty against his former side in a thrilling 4-4 Premier League draw on Sunday.
Lewis, 18, has been namechecked by Southgate on numerous occasions and was part of the City side that won the Treble last season.
Aston Villa defender Konsa, 26, won the Under-20 World Cup with England in 2017 and has helped his club side to fifth in the Premier League this season.
England have already qualified for the European Championship in Germany next June and July after a 3-1 win against Italy in October.
